cathepsin k — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T64159	Cathepsin K inhibitor 2
	Cathepsin K inhibitor 2 is a potent inhibitor of cathepsin K. Cathepsin K (Cat K) is a cysteine protease expressed under the control of the CTSK gene, which is closely related to osteoporosis and hydrolyses collagen. cat...
T72296	Cathepsin K inhibitor 3
	Cathepsin K Inhibitor 3, exhibiting an IC50 value of 0.5 nM, is a highly selective inhibitor of cathepsin K, featuring a favorable pharmacokinetic profile. It holds potential for use in studies of osteoarthritis (OA).
TP1015	NFAT Inhibitor	VIVIT peptide	Others
	NFAT Inhibitor (VIVIT peptide) is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT.		Others
T16394	ONO-5334		Cysteine Protease
	ONO-5334 is an effective and selective cathepsin K inhibitor (Ki: 0.10 nM, 0.049 nM, and 0.85 nM for human, rabbit, and rat cathepsin K, respectively). ONO-5334 has the potential for the study of osteoporosis.		Cysteine Protease
T6035	Odanacatib	MK-0822	Cysteine Protease
	Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.		Cysteine Protease
T21616	L-006235	L 006235	Cysteine Protease
	L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.		Cysteine Protease
T6015	Cathepsin Inhibitor 1		Cysteine Protease
	Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.		Cysteine Protease
T16089	MK-0674		Cysteine Protease
	MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabolism-related diseases.		Cysteine Protease
T7451	2-Cyanopyrimidine	2-cyano-Pyrimidine	Cysteine Protease
	2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)		Cysteine Protease
T1850	Balicatib	AAE581	Cysteine Protease
	Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.		Cysteine Protease
T6432	Calpeptin		Apoptosis , Cysteine Protease , Proteasome
	Calpeptin is a potent, cell-permeable calpain inhibitor.		Apoptosis , Cysteine Protease , Proteasome
T16092	L-873724		Others
	L-873724 inhibits bone resorption. L-873724 is an effective, selective, and reversible non-basic cathepsin K inhibitor (IC50s: 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respective...		Others
T71603	MV061194
	MV061194 is a potent and selective cathepsin K (Cat K) inhibitor.
T40463	Relacatib	SB-462795
	Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relac...
T24564	NVP-ABJ688	ABJ-688,ABJ 688,ABJ688
	NVP-ABJ688 is the cysteine protease cathepsin K inhibitor.
T60838	Gü2602
	Gü2602 inhibits the cathepsin K zymogen autocatalytic activation that is a potent, reversible inhibitor of cathepsin K (CatK) with a Ki of 0.013 nM for mature CatK (mCatK) [1].
T74154	ABP 25
	ABP 25 is a highly potent and selective activity-based probe (ABP) for cathepsin K imaging.
T61413	Gü1303
	Gü1303 is a highly potent and reversible inhibitor of Cathepsin K (CatK), with a Ki value of 0.91 nM for mature CatK (mCatK). This compound effectively suppresses the autocatalytic activation of the CatK zymogen [1].
T80092	Z-Gly-Pro-Arg-AMC hydrochloride
	Z-Gly-Pro-Arg-AMC hydrochloride is a fluorescent substrate for both trypsin and cathepsin K, utilized to assay their respective enzymatic activities [1] [2].
T80108	Hepcidin-1 (mouse)
	Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion. This compound also reduces FPN1 protein levels and boosts intra...
T62494	Cathepsin C-IN-5
	Cathepsin C-IN-5 (compound SF38) is a potent, selective, and orally active inhibitor of Cathepsin C, demonstrating IC50 values of 59.9 nM for Cat C, and showing significantly lower potency against Cat L (4.26 µM), Cat S,...
T78037	Hepcidin-1 (mouse) TFA
	Hepcidin-1 (mouse) TFA, an endogenous peptide hormone, regulates iron homeostasis by upregulating mRNA levels of TRAP, cathepsin K, and MMP-9, enhancing TRAP-5b protein secretion, and downregulating FPN1 protein levels, ...
T11864	Iptacopan	LNP023	Others
	Iptacopan (LNP023) is an inhibitor with high affinity for factor B.		Others

Compounds

Cathepsin K inhibitor 2

T64159

Synonym:

Target:

Cathepsin K inhibitor 3

Synonym: VIVIT peptide

Target: Cysteine Protease

Odanacatib

T6035

Synonym: MK-0822

Target: Cysteine Protease

L-006235

T21616

Synonym: L 006235

Target: Cysteine Protease

Cathepsin Inhibitor 1

T6015

Synonym:

Target: Cysteine Protease

MK-0674

T16089

Synonym:

Target: Cysteine Protease

2-Cyanopyrimidine

T7451

Synonym: 2-cyano-Pyrimidine

Target: Cysteine Protease

Balicatib

T1850

Synonym: AAE581

Target: Cysteine Protease

Calpeptin

T6432

Synonym:

Target: Apoptosis, Cysteine Protease, Proteasome

Synonym: ABJ-688,ABJ 688,ABJ688

Z-Gly-Pro-Arg-AMC hydrochloride

Hepcidin-1 (mouse) TFA

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-02565	Cathepsin K Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Thiol protease involved in osteoclastic bone resorption. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thy...
TMPH-03262	Cathepsin K Protein, Rat, Recombinant (His)	Rat	E. coli
	Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in...
TMPH-01061	Cathepsin K Protein, Human, Recombinant (His)	Human	E. coli
	Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in...

Cathepsin K Protein, Mouse, Recombinant (His)

TMPH-02565

Species: Mouse

Expression System: E. coli

Cathepsin K Protein, Rat, Recombinant (His)

TMPH-03262

Species: Rat

Expression System: E. coli

Cathepsin K Protein, Human, Recombinant (His)

TMPH-01061

Species: Human

Expression System: E. coli

Search Result

Compounds

Recombinant Proteins

Compounds

Recombinant Proteins